The Tigers are currently tied for second place in the conference with three games remaining, while Guilford, fresh off a 28-21 win over Randolph-Macon, sits in sole possession of first place at 4-0. Both teams control their own destiny, but the outcome of this game will go a long way for the winner.
A win for the Tigers forces a tie at the top, with Hampden-Sydney holding the tie breaker over Guilford.
A win for Guilford, however, would give the Tigers two losses and elevate the Quakers to a perfect 5-0 with wins over both current second-place teams Hampden-Sydney and Randolph-Macon.
In the series between these two schools that began in 1920, the Tigers hold a 40-22 advantage, including the last 13 straight wins, all under Marty Favret.